Search:
  • GENE_NAME : CD1A

    CD_NAME : CD1a

    DESC: CD1A antigen; a polypeptide
    OTH_NAMES: CD1
    CLONE_NAME ISO_TYPE SUBMITTER AVAILABLE_FROM
    Leu-6 IgG2bk  Warner  eBioscience
    O10 unknown  Boumsell  AbD Serotec
    HI149 IgG1  Chen  BioLegend
    HI149 IgG1  Chen  eBioscience
    HI149 IgG1  Chen  BD Biosciences
    HI149 IgG1  Chen  eBioscience
    HI149 IgG1  Chen  BD Biosciences
    HI149 IgG1  Chen  BioLegend
  • CLONE_NAME ISO_TYPE SUBMITTER AVAILABLE_FROM
    10D12.2 IgG1  Mawas 
    10H39.3 unknown  Mawas 
    B17.20.9 IgG2a  Immunotech 
    BL6 IgG1  Brochier 
    BL-THY1 IgG1  Fiebig 
    D47 IgG2a  Boumsell 
    I19 IgG2b  Bernard 
    JOR-T6 IgG3  Amador 
    L6 IgG2a  Kikuchi 
    L119 IgG1  Bernard 
    L232 IgG  Bernard 
    L404 IgG1  Bernard 
    L544 IgG1  Boumsell 
    L544 IgG1  Bernard 
    Leu-6 IgG2bk  Warner  eBioscience
    LO-CD1a IgG2a  Ravoet 
    M-T102 IgG2bk  Rieber 
    M-T103 IgG3  Rieber 
    M-T104 IgG2a  Rieber 
    NA1/34 IgG2a  McMichael 
    O10 unknown  Boumsell  AbD Serotec
    O605 unknown  Boumsell 
    O619 IgG2a  Boumsell 
    OKT6 IgG1  Ortho 
    T6 IgG1  Reinherz 
    UN5 IgG2a  Venuta 
    VIT6 unknown  Knapp 
    VIT6b unknown  Knapp 
    VIT6c IgG1  Knapp 
    VIT6d unknown  Knapp 
    WM35 IgG2b  Favaloro 
    WuT6 IgG2a  Wang 
    HI149 IgG1  Chen  BioLegend
    HI149 IgG1  Chen  eBioscience
    HI149 IgG1  Chen  BD Biosciences
    HI149 IgG1  Chen  eBioscience
    HI149 IgG1  Chen  BD Biosciences
    HI149 IgG1  Chen  BioLegend
  • STRUCTURE


    CD1a is a non-polymorphic type 1 integral glycoprotein with a similar structure to MHC class I molecules. CD1a is composed of a short cytoplasmic tail, a transmembrane domain and an extracellular part that contains 3 α domains.1-2 The α1 and α2 domains bind to the ligand.2 The α3 domain interacts with β-2 microglobulin forming a heterodimer. 2

     

    1. Kaczmarek R, Pasciak M, Szymczak-Kulus K, Czerwinski M. CD1: A Singed Cat of the Three Antigen Presentation Systems. Arch Immunol Ther Exp (Warsz). 2017;65:201-214.
    2. Zajonc DM. The CD1 family: serving lipid antigens to T cells since the Mesozoic era. Immunogenetics. 2016;68:561-76.

     

  • LIGANDS


    Extracellular

    CD1a ligands are sulfatide1, didehydroxymycobactins2, phosphatidylcholine and phosphatidylethanolamine3, urushiol4, squalene5, triacylglyceride5, wax esters5, and the TCR.6 It associates with β-2 microglobulin, MHC class II, invariant chain and CD9 in cis.7-8

     

    Intracellular associate molecules

    No intracellular associate molecules have been reported.

    1. Zajonc DM, Elsliger MA, Teyton L, Wilson IA. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. Nat Immunol. 2003;4:808-15.
    2. Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O'Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB. T cell activation by lipopeptide antigens. Science. 2004;303:527-31.
    3. Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, Postle AD, De Libero G, Porcelli SA, Spinozzi F. Human CD1-restricted T cell recognition of  lipids from pollens. J Exp Med. 2005;202:295-308.
    4. Kim JH, Hu Y, Yongqing T, Kim J, Hughes VA, Le Nours J, Marquez EA, Purcell AW, Wan Q, Sugita M, Rossjohn J, Winau F. CD1a on Langerhans cells controls inflammatory skin disease. Nat Immunol. 2016;17:1159-66.
    5. De Jong A, Cheng TY, Huang S, Gras S, Birkinshaw RW, Kasmar AG, Van Rhijn I, Peña-Cruz V, Ruan DT, Altman JD, Rossjohn J, Moody DB. CD1a-autoreactive T cells  recognize natural skin oils that function as headless antigens. Nat Immunol. 2014;15:177-85.
    6. Birkinshaw RW, Pellicci DG, Cheng TY, Keller AN, Sandoval-Romero M, Gras S, de Jong A, Uldrich AP, Moody DB, Godfrey DI, Rossjohn J. αβ T cell antigen receptor  recognition of CD1a presenting self lipid ligands. Nat Immunol. 2015;16:258-66.
    7. Zajonc DM. The CD1 family: serving lipid antigens to T cells since the Mesozoic era. Immunogenetics. 2016;68:561-76.
    8. Sloma I, Zilber MT, Vasselon T, Setterblad N, Cavallari M, Mori L, De Libero G, Charron D, Mooney N, Gelin C. Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts. J Immunol. 2008;180:980-7.

  • GENE_NAME : CD1A

    CD_NAME : CD1a

    CD1a is highly expressed on Langerhans cells.1 CD1a is also expressed on dendritic cells and on thymocytes, with higher intensity in double-positive and with lesser in single-positive.

    1. Kaczmarek R, Pasciak M, Szymczak-Kulus K, Czerwinski M. CD1: A Singed Cat of the Three Antigen Presentation Systems. Arch Immunol Ther Exp (Warsz). 2017;65:201-214.
    2. Coventry B, Heinzel S. CD1a in human cancers: a new role for an old molecule.  Trends Immunol. 2004;25:242-8.

  • GENE_NAME : CD1A

    CD_NAME : CD1a

    CD1a, as other members of the CD1 family, is involved in the immune response by presenting self and non-self lipid and glycolipid antigens to T cells.1 Interestingly, CD1a participates in bee and wasp venom allergy and in antitumor immune responses.2-3

    1. Coventry B, Heinzel S. CD1a in human cancers: a new role for an old molecule.  Trends Immunol. 2004;25:242-8.
    2. Subramaniam S, Aslam A, Misbah SA, Salio M, Cerundolo V, Moody DB, Ogg G. Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals. Eur J Immunol. 2016;46:242-52.
    3. La Rocca G, Anzalone R, Bucchieri F, Farina F, Cappello F, Zummo G. CD1a and antitumour immune response. Immunol Lett. 2004;95:1-4.

  • GENE_NAME : CD1A

    CD_NAME : CD1a

    Cell marker

    Used for diagnosis and characterization of T-cell precursor acute lymphoblastic leukemia/lymphoma1. It is also useful as a marker of Langerhans cells and dendritic cells.2 Furthermore, the number of CD1a-positive dendritic cells is associated with a better prognosis in ovarian cancer, papillary thyroid carcinoma, squamous cell carcinoma of the tongue and oral squamous cell carcinoma.3-6

    1. van Dongen JJ, Lhermitte L, Böttcher S, Almeida J, van der Velden VH, Flores-Montero J, Rawstron A, Asnafi V, Lécrevisse Q, Lucio P, Mejstrikova E, Szczepański T, Kalina T, de Tute R, Brüggemann M, Sedek L, Cullen M, Langerak AW, Mendonça A, Macintyre E, Martin-Ayuso M, Hrusak O, Vidriales MB, Orfao A; EuroFlow Consortium (EU-FP6, LSHB-CT-2006-018708). EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive  and malignant leukocytes. Leukemia.;26:1908-75.
    2. Coventry B, Heinzel S. CD1a in human cancers: a new role for an old molecule. Trends Immunol. 2004;25:242-8.
    3. Eisenthal A, Polyvkin N, Bramante-Schreiber L, Misonznik F, Hassner A, Lifschitz-Mercer B. Expression of dendritic cells in ovarian tumors correlates with clinical outcome in patients with ovarian cancer. Hum Pathol. 2001;32:803-7.
    4. Goldman SA, Baker E, Weyant RJ, Clarke MR, Myers JN, Lotze MT. Peritumoral CD1a-positive dendritic cells are associated with improved survival in patients with tongue carcinoma. Arch Otolaryngol Head Neck Surg. 1998;124: 641-6.
    5.  Hilly O, Rath-Wolfson L, Koren R, Mizrachi A, Hamzany Y, Bachar G, Shpitzer T. CD1a-positive dendritic cell density predicts disease-free survival in papillary  thyroid carcinoma. Pathol Res Pract. 2015;211:652-6.
    6. Jardim JF, Gondak R, Galvis MM, Pinto CAL, Kowalski LP. A decreased peritumoral CD1a+ cell number predicts a worse prognosis in oral squamous  cell carcinoma. Histopathology. 2017 Oct 11.

    Therapeutic

    To our knowledge, no therapy targeting CD1a has been approved. However, a preliminary study of anti-CD1a antibodies has shown to decrease inflammation in inflammatory skin disease.1

    1. Kim JH, Hu Y, Yongqing T, Kim J, Hughes VA, Le Nours J, Marquez EA, Purcell AW, Wan Q, Sugita M, Rossjohn J, Winau F. CD1a on Langerhans cells controls inflammatory skin disease. Nat Immunol. 2016 Oct;17(10):1159-66. doi: 10.1038/ni.3523. Epub 2016 Aug 22.

  • GENE_NAME : CD1A

    CD_NAME : CD1a

    GENERAL_INFORMATION

    NCBI_NAME CD1A
    NCBI_OTHER_NAME CD1
    SWISS_NAMES CD1A_HUMAN
    DESC CD1A antigen; a polypeptide

    LOCUS_INFO_LINKS

    HGNC_LOCUS_TAG: 1634
    ONLINE_MENDELIAN_INHERITANCE: 188370
    NCBI_HOMOLOGENE: 113556
    NCBI_MAP: 1q22-q23
    NCBI_ENTRE_GENE_ENTRY: 909
    GENE_SIZE: 4109
    EN_GE_EN:
    MRNA_SEQ_LENGTH: 2072
    PRCORENC: 534 to 1517
    ENTREN: ENST00000289429
    PROTEIN_LENGTH_NCBI_REFSEQ: 324
    NCBI_REF_SEF_ENTRY: NP_001754 , 27764865
    PROTEIN_LENGTH_SWISPROT: 327
    ENSEMBLE_PROT_ENTRY: ENSP00000289429
    PR_MO_WEIGHT: 37172
    SWPROT_PROTEIN_ENTRY: CD1A_HUMAN , P06126
    PR_SW_PR: 6.44
    IPI_NUMBER: IPI00025382
    NCBI_CONSV_DOMAINS: 27764865
    ENSM_NUMBER: P06126

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